Version 5.4
Bos taurus Gene: DOK7
Summary
InnateDB Gene IDBG-643503.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK7
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009742
Encoded Proteins
IDBP-696057
docking protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175920:
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:107234731-107252591
Strand Reverse strand
Band
Transcripts
ENSBTAT00000044179 ENSBTAP00000041693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007528 neuromuscular junction development
GO:0043113 receptor clustering
GO:0061098 positive regulation of protein tyrosine kinase activity
Cellular Component
GO:0031594 neuromuscular junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000175920
View Gene Order
ENSMUSG00000044716
View Gene Order
Cross-References
SwissProt
TrEMBL F1N754
UniProt Splice Variant
Entrez Gene 524590
UniGene
RefSeq XM_005208222
HUGO HGNC:26594
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018457
GenPept
RNA Seq Atlas 524590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca