Version 5.4
| Bos taurus Gene: MAPK11 | |||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||
| InnateDB Gene | IDBG-642533.3 | ||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
| Gene Symbol | MAPK11 | ||||||||||||||||||||||||
| Gene Name | mitogen-activated protein kinase 11 | ||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000030182 | ||||||||||||||||||||||||
| Encoded Proteins |
mitogen-activated protein kinase 11
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| Protein Structure | |||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185386:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. [provided by RefSeq, Jul 2008] This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
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| Gene Information | |||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||
| Genomic Location | Chromosome 5:119832293-119837101 | ||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
| NETPATH |
TCR pathway
IL4 pathway
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| REACTOME |
ERK/MAPK targets pathway
Activation of the AP-1 family of transcription factors pathway
activated TAK1 mediates p38 MAPK activation pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
p38MAPK events pathway
Signalling to RAS pathway
KSRP destabilizes mRNA pathway
DSCAM interactions pathway
CDO in myogenesis pathway
Cellular responses to stress pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Cell-Cell communication pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Signaling by VEGF pathway
Mitochondrial biogenesis pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Myogenesis pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Cellular Senescence pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Activated TLR4 signalling pathway
Nuclear Events (kinase and transcription factor activation) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Organelle biogenesis and maintenance pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
ERK/MAPK targets pathway
KSRP destabilizes mRNA pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Myogenesis pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
DSCAM interactions pathway
Cellular Senescence pathway
Signalling to RAS pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
CDO in myogenesis pathway
p38MAPK events pathway
VEGFA-VEGFR2 Pathway pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
NOD1/2 Signaling Pathway pathway
MyD88 dependent cascade initiated on endosome pathway
Signalling by NGF pathway
Gene Expression pathway
Developmental Biology pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
NGF signalling via TRKA from the plasma membrane pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Mitochondrial biogenesis pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cell-Cell communication pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Nuclear Events (kinase and transcription factor activation) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
GnRH signaling pathway pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
MAPK signaling pathway pathway
Leukocyte transendothelial migration pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Shigellosis pathway
Toxoplasmosis pathway
Hepatitis C pathway
VEGF signaling pathway pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Leukocyte transendothelial migration pathway
Amyotrophic lateral sclerosis (ALS) pathway
Neurotrophin signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TGF-beta signaling pathway
BMP2 signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
BMP2 signaling pathway
TGF-beta signaling pathway
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| PID NCI |
Signaling events mediated by VEGFR1 and VEGFR2
Regulation of p38-alpha and p38-beta
Plasma membrane estrogen receptor signaling
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| Cross-References | |||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||
| TrEMBL | A1A4H8 G3X793 | ||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||
| Entrez Gene | 618906 | ||||||||||||||||||||||||
| UniGene | Bt.40394 | ||||||||||||||||||||||||
| RefSeq | NM_001080335 XM_005198558 | ||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||
| EMBL | BC126500 DAAA02015043 | ||||||||||||||||||||||||
| GenPept | AAI26501 | ||||||||||||||||||||||||
| RNA Seq Atlas | 618906 | ||||||||||||||||||||||||