InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PPAT

Summary

InnateDB Gene

IDBG-642518.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPAT

Gene Name

amidophosphoribosyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010571

Encoded Proteins

IDBP-694979

amidophosphoribosyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128059:
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:73448407-73487539

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000052667

ENSBTAP00000047788

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004044	amidophosphoribosyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0008152	metabolic process
GO:0009113	purine nucleobase biosynthetic process
GO:0009116	nucleoside metabolic process