Version 5.4
| Bos taurus Gene: RBX1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-641854.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | RBX1 | ||||||||
| Gene Name | Ring-box 1; Uncharacterized protein | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000030225 | ||||||||
| Encoded Proteins |
RING-box protein 1
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100387:
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:112685001-112697359 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 158 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
Notch pathway
TGF_beta_Receptor pathway
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| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Interleukin-1 signaling pathway
Prolactin receptor signaling pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Degradation of beta-catenin by the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
truncated APC mutants destabilize the destruction complex pathway
Cellular responses to stress pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
Cytokine Signaling in Immune system pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Cellular response to hypoxia pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Nuclear signaling by ERBB4 pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by Wnt pathway
Prolactin receptor signaling pathway
Hedgehog 'off' state pathway
Signaling by WNT in cancer pathway
Cellular responses to stress pathway
degradation of DVL pathway
Signaling by ERBB4 pathway
Degradation of beta-catenin by the destruction complex pathway
Cytokine Signaling in Immune system pathway
Cellular response to hypoxia pathway
AMER1 mutants destabilize the destruction complex pathway
Immune System pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by Interleukins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Hedgehog pathway
Interleukin-1 signaling pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
Signaling by NOTCH pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG |
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
Renal cell carcinoma pathway
Ubiquitin mediated proteolysis pathway
Circadian rhythm pathway
Nucleotide excision repair pathway
Pathways in cancer pathway
Oocyte meiosis pathway
Protein processing in endoplasmic reticulum pathway
Renal cell carcinoma pathway
Ubiquitin mediated proteolysis pathway
TGF-beta signaling pathway pathway
Wnt signaling pathway pathway
Cell cycle pathway
Circadian rhythm pathway
Nucleotide excision repair pathway
Pathways in cancer pathway
Oocyte meiosis pathway
Protein processing in endoplasmic reticulum pathway
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| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
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| PID NCI |
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | Bt.105973 | ||||||||
| RefSeq | |||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||