Version 5.4
Bos taurus Gene: RFC1
Summary
InnateDB Gene IDBG-641717.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFC1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014515
Encoded Proteins
IDBP-694114
replication factor C (activator 1) 1, 145kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035928:
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3\' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:60074591-60086403
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019296 ENSBTAP00000019296
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005794 Golgi apparatus
GO:0030054 cell junction
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000035928
View Gene Order
ENSMUSG00000029191
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1993
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_378
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03430
Mismatch repair pathway
mmu03030
DNA replication pathway
mmu03420
Nucleotide excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_003582324 XM_003586196
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca