Version 5.4
Bos taurus Gene: PLA2G6
Summary
InnateDB Gene IDBG-641594.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G6
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014015
Encoded Proteins
IDBP-693993
phospholipase A2, group VI (cytosolic, calcium-independent)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184381:
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110404232-110450529
Strand Reverse strand
Band
Transcripts
ENSBTAT00000037697 ENSBTAP00000037521
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0032049 cardiolipin biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000184381
View Gene Order
ENSMUSG00000042632
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_121006
Acyl chain remodeling of CL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
REACT_239142
Innate Immune System pathway
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199034
Acyl chain remodeling of CL pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
mmu00564
Glycerophospholipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BB89
UniProt Splice Variant
Entrez Gene 535381
UniGene Bt.109508
RefSeq XM_001251754 XM_002687923 XM_005198502 XM_005207366
HUGO HGNC:9039
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014653
GenPept
RNA Seq Atlas 535381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca