Version 5.4
| Bos taurus Gene: LTBR | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-640501.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LTBR | ||||||||
| Gene Name | tumor necrosis factor receptor superfamily member 3 precursor | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000015312 | ||||||||
| Encoded Proteins |
tumor necrosis factor receptor superfamily member 3
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation from Orthologs | |||||||||
| Summary |
[Homo sapiens] LTBR signalling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection.
[Homo sapiens] LTBR signalling in the gut lymphoid follicles regulates IL22 production by innate lymphoid cells in response to mucosal pathogen challenge. (Demonstrated in mouse)
[Mus musculus] Ltbr signalling in the gut lymphoid follicles regulates Il22 production by innate lymphoid cells in response to mucosal pathogen challenge.
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| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111321:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:104346662-104354420 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
Intestinal immune network for IgA production pathway
Cytokine-cytokine receptor interaction pathway
Intestinal immune network for IgA production pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | A6QQ46 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 504653 | ||||||||
| UniGene | Bt.38184 | ||||||||
| RefSeq | NM_001103228 XM_005207174 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC149639 DAAA02014466 | ||||||||
| GenPept | AAI49640 | ||||||||
| RNA Seq Atlas | 504653 | ||||||||