InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.26197

Summary

InnateDB Gene

IDBG-640466.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.26197

Gene Name

caspase recruitment domain-containing protein 9

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006572

Encoded Proteins

IDBP-692731

caspase recruitment domain-containing protein 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19076343

[Homo sapiens] CARD9 signalling mediates mammalian innate immune responses against selected fungi, bacteria, and viruses and can prime and shape adaptive immunity. CARD9 plays an essential role in downstream signalling of the antifungal pattern-recognition receptor CLEC7A (Dectin-1).

PMID 20351059

[Homo sapiens] CARD9 is critical for full activation of innate immunity by converging signals downstream of multiple pattern recognition receptors (PRRs) and plays a pivotal role in autonomous innate host defence against tuberculosis.

PMID 20351059

[Mus musculus] Card9 is critical for full activation of innate immunity by converging signals downstream of multiple pattern recognition receptors (PRRs) and plays a pivotal role in autonomous innate host defense against tuberculosis.

PMID 24379290

[Mus musculus] Card9 is largely dispensable for the innate immune response to oropharyngeal candidiasis whereas it is vital for the adaptive Th17 response.

PMID 26627732

[Mus musculus] Card9-mediated activation of the innate immune system exacerbates influenza pneumonia. Card9 deficiency improves mortality with reduced inflammatory cytokine/chemokines.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187796:
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:103876015-103883072

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008634

ENSBTAP00000008634

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050700	CARD domain binding

Biological Process

GO:0009620	response to fungus
GO:0032494	response to peptidoglycan
GO:0032495	response to muramyl dipeptide
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0042493	response to drug
GO:0042534	regulation of tumor necrosis factor biosynthetic process
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330	response to exogenous dsRNA
GO:0045076	regulation of interleukin-2 biosynthetic process
GO:0045089	positive regulation of innate immune response
GO:0045408	regulation of interleukin-6 biosynthetic process
GO:0046330	positive regulation of JNK cascade
GO:0050830	defense response to Gram-positive bacterium
GO:0051607	defense response to virus