Version 5.4
Bos taurus Gene: POR
Summary
InnateDB Gene IDBG-640106.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POR
Gene Name NADPH--cytochrome P450 reductase
Synonyms P450R
Species Bos taurus
Ensembl Gene ENSBTAG00000017082
Encoded Proteins
IDBP-692326
NADPH--cytochrome P450 reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127948:
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 25:34672093-34726073
Strand Forward strand
Band
Transcripts
ENSBTAT00000022718 ENSBTAP00000022718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003958 NADPH-hemoprotein reductase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0032770 positive regulation of monooxygenase activity
GO:0055114 oxidation-reduction process
GO:0090346 cellular organofluorine metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000127948
View Gene Order
ENSMUSG00000005514
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3SYT8
TrEMBL A5D9D3 Q45V79
UniProt Splice Variant
Entrez Gene 532512
UniGene Bt.41220
RefSeq NM_001035390
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103399 BT030552 DAAA02058200 DQ109574
GenPept AAI03400 AAZ17651 ABQ12992
RNA Seq Atlas 532512

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca