InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.11942

Summary

InnateDB Gene

IDBG-640007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.11942

Gene Name

collagen alpha-1(XVIII) chain precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000023907

Encoded Proteins

IDBP-692231

collagen alpha-1(XVIII) chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182871:
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:146989244-147040968

Strand

Forward strand

Band

Transcripts

ENSBTAT00000034655

ENSBTAP00000034542

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001886	endothelial cell morphogenesis
GO:0007155	cell adhesion
GO:0008284	positive regulation of cell proliferation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005581	collagen trimer
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome