Bos taurus Gene: ASL | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-639750.3 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | ASL | ||||||||||
Gene Name | argininosuccinate lyase | ||||||||||
Synonyms | ASAL | ||||||||||
Species | Bos taurus | ||||||||||
Ensembl Gene | ENSBTAG00000015314 | ||||||||||
Encoded Proteins |
argininosuccinate lyase
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126522:
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 25:28247949-28256721 | ||||||||||
Strand | Reverse strand | ||||||||||
Band | |||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism pathway
Urea cycle pathway
Metabolism of amino acids and derivatives pathway
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KEGG |
Arginine and proline metabolism pathway
Alanine, aspartate and glutamate metabolism pathway
Arginine and proline metabolism pathway
Alanine, aspartate and glutamate metabolism pathway
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INOH |
Arginine Proline metabolism pathway
Citrate cycle pathway
Alanine Aspartate Asparagine metabolism pathway
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PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | F1MTV7 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 512771 | ||||||||||
UniGene | Bt.10013 | ||||||||||
RefSeq | NM_001034428 XM_005224888 XM_005224889 XM_005224890 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | DAAA02057948 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 512771 | ||||||||||