InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCC9

Summary

InnateDB Gene

IDBG-638900.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCC9

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019294

Encoded Proteins

IDBP-691056

ATP-binding cassette, sub-family C (CFTR/MRP), member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069431:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:88677586-88831324

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043069

ENSBTAP00000040663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005267	potassium channel activity
GO:0005524	ATP binding
GO:0008281	sulfonylurea receptor activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0044325	ion channel binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006813	potassium ion transport
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0051607	defense response to virus
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0042383	sarcolemma