Bos taurus Gene: IL4R | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-638778.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | IL4R | ||||||||||||||
Gene Name | interleukin-4 receptor subunit alpha precursor | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000001602 | ||||||||||||||
Encoded Proteins |
interleukin-4 receptor subunit alpha
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] IL4R is utilized by IL13 to induce phosphorylation and activation of JAK2 in human colon carcinoma cell lines.
[Homo sapiens] The IL4R signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis. (Demonstrated in mice)
[Mus musculus] The Il4ra signalling pathway contributes to the heightened susceptibility of mice co-infected with Mycobacterium tuberculosis and the intestinal helminth, Nippostrongylus brasiliensis
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077238:
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 25:25139417-25189373 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
IL4 pathway
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REACTOME | |||||||||||||||
KEGG |
Hematopoietic cell lineage pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
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INOH |
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
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PID NCI |
p73 transcription factor network
IL4-mediated signaling events
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Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | Q148M2 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 404154 | ||||||||||||||
UniGene | Bt.45933 | ||||||||||||||
RefSeq | NM_001075142 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC118151 DAAA02057867 | ||||||||||||||
GenPept | AAI18152 | ||||||||||||||
RNA Seq Atlas | 404154 | ||||||||||||||