Version 5.4
Bos taurus Gene: LARGE
Summary
InnateDB Gene IDBG-637848.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LARGE
Gene Name glycosyltransferase-like protein LARGE1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021953
Encoded Proteins
IDBP-689889
like-glycosyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133424:
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:72157229-72769395
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029269 ENSBTAP00000029269
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0008152 metabolic process
GO:0046716 muscle cell cellular homeostasis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000133424
View Gene Order
ENSMUSG00000004383
View Gene Order
Cross-References
SwissProt
TrEMBL E1BDI0
UniProt Splice Variant
Entrez Gene 506466
UniGene Bt.108249 Bt.29331
RefSeq NM_001205588 XM_005206780 XM_005206781 XM_005206782 XM_005206783
HUGO HGNC:6511
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013760 DAAA02013761 DAAA02013762 DAAA02013763 DAAA02013764 DAAA02013765 DAAA02013766 DAAA02013767 DAAA02013768 DAAA02013769 DAAA02013770 DAAA02013771
GenPept
RNA Seq Atlas 506466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca