InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLX4

Summary

InnateDB Gene

IDBG-636021.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLX4

Gene Name

Uncharacterized protein

Synonyms

BTBD12

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004509

Encoded Proteins

IDBP-687911

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24412650

[Homo sapiens] HIV auxiliary protein Vpr directly activates SLX4 to promote cell cycle arrest at the G2/M, a process that requires VPRBP-DDB1-CUL4 E3-ligase complex, to escape from innate immune sensing.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188827:
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:2958710-2977159

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005923

ENSBTAP00000005923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008821	crossover junction endodeoxyribonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0048257	3'-flap endonuclease activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0043085	positive regulation of catalytic activity
GO:0072429	response to intra-S DNA damage checkpoint signaling

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0033557	Slx1-Slx4 complex
GO:0048476	Holliday junction resolvase complex
GO:0070522	ERCC4-ERCC1 complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000188827

View Gene Order

ENSMUSG00000039738

View Gene Order

Cross-References

SwissProt

TrEMBL

F1N7Q0

UniProt Splice Variant

Entrez Gene

512193

UniGene

Bt.105502 Bt.105578 Bt.111638 Bt.20047

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02057328 GJ062847

GenPept

DAA15665

RNA Seq Atlas

512193