Version 5.4
| Bos taurus Gene: MLST8 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-635283.3 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | MLST8 | ||||||||||
| Gene Name | Target of rapamycin complex subunit LST8 | ||||||||||
| Synonyms | GBL | ||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Gene | ENSBTAG00000009928 | ||||||||||
| Encoded Proteins |
Target of rapamycin complex subunit LST8
Target of rapamycin complex subunit LST8
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| Protein Structure | |||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| InnateDB Annotation from Orthologs | |||||||||||
| Summary |
[Homo sapiens] MLST8 regulates TNF-alpha-induced NF-kappaB signalling by directly inhibiting the activation of IkappaB kinase.
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| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167965:
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 25:1738258-1742107 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | |||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
DAP12 interactions pathway
Insulin receptor signalling cascade pathway
CD28 dependent PI3K/Akt signaling pathway
Signaling by EGFR pathway
GAB1 signalosome pathway
S6K1-mediated signalling pathway
HSF1-dependent transactivation pathway
PKB-mediated events pathway
IRS-related events triggered by IGF1R pathway
Release of eIF4E pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
Costimulation by the CD28 family pathway
Signaling by FGFR pathway
mTOR signalling pathway
Cellular responses to stress pathway
mTORC1-mediated signalling pathway
IRS-related events pathway
VEGFA-VEGFR2 Pathway pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
IRS-mediated signalling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
IGF1R signaling cascade pathway
CD28 co-stimulation pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
VEGFR2 mediated vascular permeability pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
Signaling by EGFR in Cancer pathway
PI-3K cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
Signalling by NGF pathway
Signaling by VEGF pathway
Cellular response to heat stress pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
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| KEGG | |||||||||||
| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
PI3K/AKT activation pathway
Release of eIF4E pathway
S6K1-mediated signalling pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
PKB-mediated events pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
VEGFR2 mediated vascular permeability pathway
mTORC1-mediated signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
HSF1-dependent transactivation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Cellular response to heat stress pathway
IRS-related events pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Signaling by Insulin receptor pathway
Cellular responses to stress pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
HSF1-dependent transactivation pathway
Release of eIF4E pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
Cellular response to heat stress pathway
Insulin receptor signalling cascade pathway
S6K1-mediated signalling pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
VEGFR2 mediated vascular permeability pathway
PI3K Cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
mTORC1-mediated signalling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
mTOR signalling pathway
PKB-mediated events pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
mTOR signaling pathway pathway
mTOR signaling pathway pathway
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| INOH |
Insulin receptor signaling pathway
Insulin receptor signaling pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
ErbB1 downstream signaling
mTOR signaling pathway
LKB1 signaling events
CXCR3-mediated signaling events
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| Cross-References | |||||||||||
| SwissProt | |||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | |||||||||||
| UniGene | Bt.3376 | ||||||||||
| RefSeq | NM_001035411 XM_005224526 XM_005224527 XM_005224528 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | |||||||||||
| GenPept | |||||||||||
| RNA Seq Atlas | |||||||||||