InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GCK

Summary

InnateDB Gene

IDBG-634357.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCK

Gene Name

glucokinase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000032288

Encoded Proteins

IDBP-686133

glucokinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106633:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:77820949-77857151

Strand

Forward strand

Band

Transcripts

ENSBTAT00000045734

ENSBTAP00000043100

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005536	glucose binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006096	glycolytic process
GO:0006739	NADP metabolic process
GO:0016310	phosphorylation
GO:0032024	positive regulation of insulin secretion
GO:0042593	glucose homeostasis
GO:0043266	regulation of potassium ion transport
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046835	carbohydrate phosphorylation
GO:0050796	regulation of insulin secretion
GO:0051156	glucose 6-phosphate metabolic process
GO:0051594	detection of glucose
GO:0070509	calcium ion import