Bos taurus Gene: DERL2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||
InnateDB Gene | IDBG-633968.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | DERL2 | ||||||||||||
Gene Name | derlin-2 | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000020431 | ||||||||||||
Encoded Proteins |
Der1-like domain family, member 2
|
||||||||||||
Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072849:
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[supplied by OMIM, Mar 2008] |
||||||||||||
Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 19:26683195-26691719 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | |||||||||||||
Transcripts |
|
||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
|
||||||||||||
Gene Ontology | |||||||||||||
Molecular Function |
|
||||||||||||
Biological Process |
|
||||||||||||
Cellular Component |
|
||||||||||||
Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Disease pathway
Disease pathway
Hedgehog ligand biogenesis pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Hh ligand biogenesis disease pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
|
||||||||||||
KEGG |
Protein processing in endoplasmic reticulum pathway
Protein processing in endoplasmic reticulum pathway
|
||||||||||||
INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | |||||||||||||
RefSeq | NM_001035059 XM_005220202 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||