InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RGS11

Summary

InnateDB Gene

IDBG-633582.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS11

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016574

Encoded Proteins

IDBP-685365

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076344:
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:292324-299280

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022048

ENSBTAP00000022048

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0044292	dendrite terminus

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000076344

View Gene Order

ENSMUSG00000024186

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

KEGG

INOH

INOH website

GPCR signaling pathway

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.26392

RefSeq

NM_001075814 XM_005200988 XM_005200989

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas