Version 5.4
| Bos taurus Gene: CHN2 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-633498.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | CHN2 | ||||||
| Gene Name | CHN2 protein; Uncharacterized protein | ||||||
| Synonyms | |||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000020931 | ||||||
| Encoded Proteins |
CHN2 protein
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106069:
This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 4:67065205-67401294 | ||||||
| Strand | Reverse strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Rho GTPase cycle pathway
Signaling by Rho GTPases pathway
Signal Transduction pathway
Signaling by Rho GTPases pathway
Rho GTPase cycle pathway
Signal Transduction pathway
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| KEGG | |||||||
| INOH | |||||||
| PID NCI |
Regulation of RAC1 activity
ErbB1 downstream signaling
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | Q0VD41 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 507285 | ||||||
| UniGene | Bt.108253 | ||||||
| RefSeq | XM_005205489 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | BC119844 DAAA02010917 | ||||||
| GenPept | AAI19845 | ||||||
| RNA Seq Atlas | 507285 | ||||||