Version 5.4
Bos taurus Gene: DROSHA
Summary
InnateDB Gene IDBG-630832.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DROSHA
Gene Name Uncharacterized protein
Synonyms RNASEN
Species Bos taurus
Ensembl Gene ENSBTAG00000017551
Encoded Proteins
IDBP-682459
drosha, ribonuclease type III
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113360:
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:42067162-42183443
Strand Forward strand
Band
Transcripts
ENSBTAT00000023346 ENSBTAP00000023346
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0003723 RNA binding
GO:0004521 endoribonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006396 RNA processing
GO:0010468 regulation of gene expression
GO:0010586 miRNA metabolic process
GO:0016075 rRNA catabolic process
GO:0031053 primary miRNA processing
GO:0031054 pre-miRNA processing
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113360
View Gene Order
ENSMUSG00000022191
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_221178
MicroRNA (miRNA) biogenesis pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL E1BGY0
UniProt Splice Variant
Entrez Gene 540168
UniGene
RefSeq
HUGO HGNC:17904
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02050706
GenPept
RNA Seq Atlas 540168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca