InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CHRNA7

Summary

InnateDB Gene

IDBG-630821.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNA7

Gene Name

neuronal acetylcholine receptor subunit alpha-7 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015775

Encoded Proteins

IDBP-682307

neuronal acetylcholine receptor subunit alpha-7 precursor

IDBP-682308

neuronal acetylcholine receptor subunit alpha-7 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175344:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008] The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:30079543-30102510

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020942	ENSBTAP00000020942
ENSBTAT00000064296	ENSBTAP00000056122

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0001988	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure
GO:0006810	transport
GO:0006811	ion transport
GO:0006897	endocytosis
GO:0007271	synaptic transmission, cholinergic
GO:0007613	memory
GO:0008306	associative learning
GO:0014061	regulation of norepinephrine secretion
GO:0030317	sperm motility
GO:0032094	response to food
GO:0032225	regulation of synaptic transmission, dopaminergic
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0042391	regulation of membrane potential
GO:0042698	ovulation cycle
GO:0045471	response to ethanol
GO:0048149	behavioral response to ethanol
GO:0050727	regulation of inflammatory response
GO:0050728	negative regulation of inflammatory response
GO:0060112	generation of ovulation cycle rhythm