InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.87929

Summary

InnateDB Gene

IDBG-630734.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.87929

Gene Name

pancreas/duodenum homeobox protein 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010690

Encoded Proteins

IDBP-682215

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139515:
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:32352254-32357227

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014141

ENSBTAP00000014141

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001889	liver development
GO:0006006	glucose metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007263	nitric oxide mediated signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0016331	morphogenesis of embryonic epithelium
GO:0030073	insulin secretion
GO:0030154	cell differentiation
GO:0031016	pancreas development
GO:0031017	exocrine pancreas development
GO:0031018	endocrine pancreas development
GO:0042127	regulation of cell proliferation
GO:0042593	glucose homeostasis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048565	digestive tract development
GO:1902236	negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000675	negative regulation of type B pancreatic cell apoptotic process