InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: APBA2

Summary

InnateDB Gene

IDBG-630524.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APBA2

Gene Name

amyloid beta A4 precursor protein-binding family A member 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020413

Encoded Proteins

IDBP-682030

amyloid beta A4 precursor protein-binding, family A, member 2

IDBP-682036

amyloid beta A4 precursor protein-binding, family A, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000034053:
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:28512734-28626134

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027205	ENSBTAP00000027205
ENSBTAT00000054946	ENSBTAP00000047822

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007268	synaptic transmission
GO:0007626	locomotory behavior
GO:0010468	regulation of gene expression
GO:0035264	multicellular organism growth

Cellular Component

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000034053

View Gene Order

ENSMUSG00000030519

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.10295 Bt.96870

RefSeq

NM_001077921 XM_005221938 XM_005221939 XM_005221940 XM_005221941 XM_005221942 XM_005221943 XM_005221944

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas