InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: THRB

Summary

InnateDB Gene

IDBG-630420.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THRB

Gene Name

Uncharacterized protein

Synonyms

TRbeta1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017802

Encoded Proteins

IDBP-681967

thyroid hormone receptor, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20018842

[Homo sapiens] THRB signalling plays a role in modulating dendritic cell (DC) physiology and has immunoregulatory effects. THRB contains an NF-kappaB consensus site in its promoter region that controls its expression, which in turn signals DCs to promote maturation and function via an Akt-dependent, but PI3K independent pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151090:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:41695665-41771738

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023670

ENSBTAP00000023670

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0007621	negative regulation of female receptivity
GO:0008016	regulation of heart contraction
GO:0008050	female courtship behavior
GO:0009887	organ morphogenesis
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060509	Type I pneumocyte differentiation