InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL7R

Summary

InnateDB Gene

IDBG-630353.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL7R

Gene Name

interleukin-7 receptor subunit alpha precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019975

Encoded Proteins

IDBP-681822

interleukin 7 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26187413

[Homo sapiens] Differentiation of Type 3 innate lymphoid cells (ILC3) to IL7R(+) ILC1 is reversible whereas IL7R(+) ILC1 can differentiate to ILC3 in the presence of IL2, IL23A, and IL1B dependent on the transcription factor RORC, and this process is enhanced in the presence of retinoic acid.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168685:
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:38335658-38368259

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026608

ENSBTAP00000026608

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0002377	immunoglobulin production
GO:0008361	regulation of cell size
GO:0010628	positive regulation of gene expression
GO:0016049	cell growth
GO:0019221	cytokine-mediated signaling pathway
GO:0030217	T cell differentiation
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0042100	B cell proliferation
GO:0048535	lymph node development
GO:0048872	homeostasis of number of cells