Version 5.4
Bos taurus Gene: ADAMTS5
Summary
InnateDB Gene IDBG-630284.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMTS5
Gene Name A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000648
Encoded Proteins
IDBP-681728
A disintegrin and metalloproteinase with thrombospondin motifs 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154736:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:8811792-8861602
Strand Forward strand
Band
Transcripts
ENSBTAT00000000849 ENSBTAP00000000849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0042742 defense response to bacterium
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154736
View Gene Order
ENSMUSG00000022894
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
REACT_211817
O-glycosylation of TSR domain-containing proteins pathway
REACT_206066
Extracellular matrix organization pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_204003
O-linked glycosylation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MRZ2
UniProt Splice Variant
Entrez Gene 286805
UniGene Bt.13108
RefSeq NM_001166515
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02000217 DAAA02000218 DAAA02000219
GenPept
RNA Seq Atlas 286805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca