InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ANGPT2

Summary

InnateDB Gene

IDBG-628426.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPT2

Gene Name

Angiopoietin-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011034

Encoded Proteins

IDBP-679781

Angiopoietin-2

IDBP-679782

Angiopoietin-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091879:
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:4422700-4481033

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014656	ENSBTAP00000014656
ENSBTAT00000011574	ENSBTAP00000011574

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0007275	multicellular organismal development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0016525	negative regulation of angiogenesis
GO:0030154	cell differentiation
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0048014	Tie signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050928	negative regulation of positive chemotaxis