Version 5.4
Homo sapiens Gene: NFKBIA
Summary
InnateDB Gene IDBG-4758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFKBIA
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Synonyms IKBA; MAD-3; NFKBI
Species Homo sapiens
Ensembl Gene ENSG00000100906
Encoded Proteins
IDBP-4760
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
IDBP-595187
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
IDBP-599374
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
IDBP-590211
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
IDBP-586415
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 9891086
NFKBIA is a common component of the heterogeneous IKK complex that mediates an essential step of the NF-kappaB signal transduction cascade by acting as an inhibitor of NF-kappaB.
PMID 12429743
Tyrosine phosphorylation of NFKBIA is c-Src-dependent, leading to the subsequent activation of NF-kappaB.
PMID 16931600
Nuclear transport of the NFKBIA : RELA complex, required for the appropriate regulation of NF-kappaB signalling, is facilitated by 14-3-3 proteins.
PMID 18503636
NFKBIA ubiquitination and degradation is inhibited by ChlaDub1, a protein of Chlamydia trachomatis, suppressing NF-kappaB activation as a result.
PMID 21454695
NFKBIA degradation occurs through the TNF-stimulated formation of autophagosomes in epithelial cells, which results in the prolonged activation of NFKB activity.
PMID 23487427
Polymorphisms in the NFKBIA promoter are associated with pediatric lung diseases, including childhood asthma, bronchiolitis and bronchopulmonary dysplasia.
PMID 26642243
Haploinsufficiency of A20 (HA20) is caused by high-penetrance loss-of-function germline mutations in TNFAIP3 with increased degradation of NFKBIA, nuclear translocation of RELA, increased expression of NFκB mediated proinflammatory cytokines, and defective deubiquitinating activity.
InnateDB Annotation from Orthologs
Summary
PMID 21454695
[Mus musculus] Nfkbia degradation occurs through the TNF-stimulated formation of autophagosomes in epithelial cells, which results in the prolonged activation of NFKB activity.
Entrez Gene
Summary This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:35401511-35404749
Strand Reverse strand
Band q13.2
Transcripts
ENST00000216797 ENSP00000216797
ENST00000554001 ENSP00000450537
ENST00000557140 ENSP00000451257
ENST00000557389 ENSP00000450514
ENST00000555371
ENST00000557100
ENST00000556664
ENST00000557459
ENST00000555629
ENST00000553342 ENSP00000451281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 234 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 234 [view]
Protein-Protein 210 [view]
Protein-DNA 23 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006915 apoptotic process
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0010468 regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0016032 viral process
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032481 positive regulation of type I interferon production
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043066 negative regulation of apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0043392 negative regulation of DNA binding
GO:0045087 innate immune response (InnateDB)
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070417 cellular response to cold
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0033256 I-kappaB/NF-kappaB complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021025
View Gene Order
ENSBTAG00000016683
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_26
TWEAK pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_12555
Downstream TCR signaling pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_12526
TCR signaling pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04210
Apoptosis pathway
hsa05222
Small cell lung cancer pathway
hsa04662
B cell receptor signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04622
RIG-I-like receptor signaling pathway pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
hsa05140
Leishmaniasis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04380
Osteoclast differentiation pathway
hsa05131
Shigellosis pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
B cell receptor signaling pathway
INOH website
TNFR1 signaling pathway pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
nfkappabatypicalpathway
Atypical NF-kappaB pathway
ceramide_pathway
Ceramide signaling pathway
lysophospholipid_pathway
LPA receptor mediated events
aurora_a_pathway
Aurora A signaling
hdac_classi_pathway
Signaling events mediated by HDAC Class I
bcr_5pathway
BCR signaling pathway
il23pathway
IL23-mediated signaling events
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL G3V3I4
UniProt Splice Variant
Entrez Gene 4792
UniGene
RefSeq NM_020529
HUGO HGNC:7797
OMIM 164008
CCDS CCDS9656
HPRD 01235
IMGT
EMBL AL133163
GenPept
RNA Seq Atlas 4792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca