Version 5.4
Homo sapiens Gene: TET2
Summary
InnateDB Gene IDBG-32690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TET2
Gene Name tet methylcytosine dioxygenase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168769
Encoded Proteins
IDBP-32692
tet methylcytosine dioxygenase 2
IDBP-32694
tet methylcytosine dioxygenase 2
IDBP-32719
tet methylcytosine dioxygenase 2
IDBP-240925
tet methylcytosine dioxygenase 2
IDBP-375318
tet methylcytosine dioxygenase 2
IDBP-480846
tet methylcytosine dioxygenase 2
IDBP-484674
tet methylcytosine dioxygenase 2
IDBP-589703
tet methylcytosine dioxygenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26287468
TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 26287468
[Mus musculus] Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:105145875-105279816
Strand Forward strand
Band q24
Transcripts
ENST00000305737 ENSP00000306705
ENST00000380013 ENSP00000369351
ENST00000265149 ENSP00000265149
ENST00000394764 ENSP00000378245
ENST00000413648 ENSP00000391448
ENST00000513237 ENSP00000425443
ENST00000504042
ENST00000505801
ENST00000514870 ENSP00000426885
ENST00000540549 ENSP00000442788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0070579 methylcytosine dioxygenase activity
Biological Process
GO:0001822 kidney development
GO:0006211 5-methylcytosine catabolic process
GO:0006493 protein O-linked glycosylation
GO:0007049 cell cycle
GO:0009791 post-embryonic development
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0055114 oxidation-reduction process
GO:0080111 DNA demethylation
GO:0080182 histone H3-K4 trimethylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040943
View Gene Order
ENSBTAG00000017682
Not yet available
Pathways
NETPATH
REACTOME
REACT_200682
TET1,2,3 and TDG demethylate DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367639 Hs.706276 Hs.740935
RefSeq NM_001127208 NM_017628 XM_005263082 XM_006714243
HUGO
OMIM
CCDS CCDS3666 CCDS47120
HPRD 07876
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca