InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sirt3

Summary

InnateDB Gene

IDBG-211875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sirt3

Gene Name

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

Synonyms

2310003L23Rik; AI848213; Sir2l3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025486

Encoded Proteins

IDBP-211877

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

IDBP-269578

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

IDBP-542568

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

IDBP-542565

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

IDBP-542562

sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142082:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:140863670-140882309

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026559	ENSMUSP00000026559
ENSMUST00000106048	ENSMUSP00000101663
ENSMUST00000137024	ENSMUSP00000114247
ENSMUST00000147331	ENSMUSP00000121151
ENSMUST00000137710	ENSMUSP00000115202

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0019899	enzyme binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006476	protein deacetylation
GO:0007568	aging
GO:0009060	aerobic respiration
GO:0034983	peptidyl-lysine deacetylation
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000142082

View Gene Order

ENSBTAG00000002044

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_200788

Mitochondrial biogenesis pathway

REACT_200608

Transcriptional activation of mitochondrial biogenesis pathway

KEGG

INOH

PID NCI

hdac_classiii_pathway

Signaling events mediated by HDAC Class III

Cross-References

SwissProt

TrEMBL

D3YVQ5 D3YWD6

UniProt Splice Variant

Entrez Gene

64384

UniGene

RefSeq

XM_006536222 XM_006536223 NM_001127351 NM_001177804 NM_022433

OMIM

CCDS

CCDS21989

HPRD

IMGT

MGI ID

MGI:1927665

MGI Symbol

Sirt3

EMBL

AC107815

GenPept

RNA Seq Atlas

64384