Version 5.4
Mus musculus Gene: Cdx2
Summary
InnateDB Gene IDBG-209013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdx2
Gene Name caudal type homeobox 2
Synonyms Cdx-2
Species Mus musculus
Ensembl Gene ENSMUSG00000029646
Encoded Proteins
IDBP-209015
caudal type homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165556:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:147300805-147307270
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000031650 ENSMUSP00000031650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 7 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0001824 blastocyst development
GO:0001829 trophectodermal cell differentiation
GO:0001890 placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007389 pattern specification process
GO:0008284 positive regulation of cell proliferation
GO:0008333 endosome to lysosome transport
GO:0009952 anterior/posterior pattern specification
GO:0030154 cell differentiation
GO:0035019 somatic stem cell maintenance
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045597 positive regulation of cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060711 labyrinthine layer development
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0017053 transcriptional repressor complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165556
View Gene Order
ENSBTAG00000001819
Not yet available
Pathways
NETPATH
REACTOME
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P43241
TrEMBL Q543L9
UniProt Splice Variant
Entrez Gene 12591
UniGene Mm.20358
RefSeq NM_007673
OMIM
CCDS CCDS19878
HPRD
IMGT
MGI ID MGI:88361
MGI Symbol Cdx2
EMBL AK049566 BC103516 BC103517 BC103519 BC103520 CH466614 S74520 U00454
GenPept AAA19645 AAB32251 AAI03517 AAI03518 AAI03520 AAI03521 BAC33814 EDL05830
RNA Seq Atlas 12591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca