Version 5.4
| Mus musculus Gene: Prkar1b | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-206405.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Prkar1b | ||||||||||||||||||||||
| Gene Name | protein kinase, cAMP dependent regulatory, type I beta | ||||||||||||||||||||||
| Synonyms | AI385716; RIbeta | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000025855 | ||||||||||||||||||||||
| Encoded Proteins |
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
protein kinase, cAMP dependent regulatory, type I beta
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188191:
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.[supplied by OMIM, Jun 2009] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 5:139017306-139150001 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | G2 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Disease pathway
Hemostasis pathway
Signaling by GPCR pathway
Glucagon signaling in metabolic regulation pathway
Hedgehog 'off' state pathway
Integration of energy metabolism pathway
Ca-dependent events pathway
Signaling by FGFR in disease pathway
DARPP-32 events pathway
PLC-gamma1 signalling pathway
PKA-mediated phosphorylation of CREB pathway
Metabolism pathway
PKA activation in glucagon signalling pathway
Immune System pathway
EGFR interacts with phospholipase C-gamma pathway
Aquaporin-mediated transport pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
CaM pathway pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Signaling by Hedgehog pathway
NGF signalling via TRKA from the plasma membrane pathway
Opioid Signalling pathway
Calmodulin induced events pathway
Signal Transduction pathway
Signaling by FGFR pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
PKA activation pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Insulin signaling pathway pathway
Apoptosis pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TGF_beta_Receptor pathway
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| REACTOME |
PKA activation pathway
PKA-mediated phosphorylation of CREB pathway
Calmodulin induced events pathway
CaM pathway pathway
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Factors involved in megakaryocyte development and platelet production pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
PLC beta mediated events pathway
DARPP-32 events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
PKA activation in glucagon signalling pathway
Glucagon signaling in metabolic regulation pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Transmembrane transport of small molecules pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Immune System pathway
NGF signalling via TRKA from the plasma membrane pathway
Metabolism pathway
Ca-dependent events pathway
Aquaporin-mediated transport pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Apoptosis pathway
Insulin signaling pathway pathway
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| INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
GPCR signaling pathway
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| PID NCI |
Alpha4 beta1 integrin signaling events
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | D3Z4L4 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 19085 | ||||||||||||||||||||||
| UniGene | Mm.306163 Mm.489445 | ||||||||||||||||||||||
| RefSeq | NM_001253890 NM_008923 XM_006504660 XM_006504661 XM_006504662 XM_006504663 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS19803 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:97759 | ||||||||||||||||||||||
| MGI Symbol | Prkar1b | ||||||||||||||||||||||
| EMBL | AC117698 AC125065 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | 19085 | ||||||||||||||||||||||