Version 5.4
Mus musculus Gene: Rabgef1
Summary
InnateDB Gene IDBG-202259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rabgef1
Gene Name RAB guanine nucleotide exchange factor (GEF) 1
Synonyms Rab5ef; Rabex5; Rin2
Species Mus musculus
Ensembl Gene ENSMUSG00000025340
Encoded Proteins
IDBP-202261
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-400212
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-400210
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-542960
RAB guanine nucleotide exchange factor (GEF) 1
IDBP-542961
RAB guanine nucleotide exchange factor (GEF) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154710:
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:130171798-130214342
Strand Forward strand
Band G1.3
Transcripts
ENSMUST00000026390 ENSMUSP00000026390
ENSMUST00000119797 ENSMUSP00000114103
ENSMUST00000119027 ENSMUSP00000112537
ENSMUST00000148264 ENSMUSP00000119245
ENSMUST00000143727
ENSMUST00000125937
ENSMUST00000147493
ENSMUST00000143865 ENSMUSP00000118590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0002686 negative regulation of leukocyte migration
GO:0006897 endocytosis
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0033004 negative regulation of mast cell activation
GO:0043305 negative regulation of mast cell degranulation
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050728 negative regulation of inflammatory response
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 negative regulation of interleukin-6 secretion
GO:1900235 negative regulation of Kit signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0031982 vesicle
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154710
View Gene Order
ENSBTAG00000003842
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.288639 Mm.474835
RefSeq NM_001199059 NM_019983 XM_006504446 XM_006504447 XM_006504448 XM_006504449
OMIM
CCDS CCDS19708
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca