Mus musculus Gene: Pak6 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-198265.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Pak6 | ||||||||||||
Gene Name | p21 protein (Cdc42/Rac)-activated kinase 6 | ||||||||||||
Synonyms | |||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Gene | ENSMUSG00000074923 | ||||||||||||
Encoded Proteins |
p21 protein (Cdc42/Rac)-activated kinase 6
p21 protein (Cdc42/Rac)-activated kinase 6
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137843:
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 2:118663303-118698020 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | E5 | ||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||
NETPATH | |||||||||||||
REACTOME |
Signaling by Robo receptor pathway
Axon guidance pathway
Developmental Biology pathway
Activation of Rac pathway
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KEGG |
Axon guidance pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH |
AndrogenReceptor pathway
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REACTOME |
Activation of Rac pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Axon guidance pathway
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KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | Mm.241857 | ||||||||||||
RefSeq | NM_001033254 NM_001145854 | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS16580 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
MGI ID | |||||||||||||
MGI Symbol | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||