InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ldhb

Summary

InnateDB Gene

IDBG-196960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ldhb

Gene Name

lactate dehydrogenase B

Synonyms

AI790582; H-Ldh; Ldh-2; LDH-B; LDH-H; Ldh2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030246

Encoded Proteins

IDBP-196962

lactate dehydrogenase B

IDBP-541976

lactate dehydrogenase B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111716:
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:142490249-142507957

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032373	ENSMUSP00000032373
ENSMUST00000130817
ENSMUST00000134191	ENSMUSP00000116014

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004457	lactate dehydrogenase activity
GO:0004459	L-lactate dehydrogenase activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006089	lactate metabolic process
GO:0006096	glycolytic process
GO:0019674	NAD metabolic process
GO:0044262	cellular carbohydrate metabolic process
GO:0055114	oxidation-reduction process