InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc12a6

Summary

InnateDB Gene

IDBG-196487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc12a6

Gene Name

solute carrier family 12, member 6

Synonyms

9530023I19Rik; gaxp; KCC3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027130

Encoded Proteins

IDBP-196489

solute carrier family 12, member 6

IDBP-196491

solute carrier family 12, member 6

IDBP-259060

solute carrier family 12, member 6

IDBP-259062

solute carrier family 12, member 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140199:
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:112265825-112363163

Strand

Forward strand

Band

Transcripts

ENSMUST00000028549	ENSMUSP00000028549
ENSMUST00000053666	ENSMUSP00000051490
ENSMUST00000110991	ENSMUSP00000106619
ENSMUST00000110987	ENSMUSP00000106615
ENSMUST00000133840
ENSMUST00000132752
ENSMUST00000156470
ENSMUST00000137896

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0015377	cation:chloride symporter activity
GO:0015379	potassium:chloride symporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006821	chloride transport
GO:0055085	transmembrane transport
GO:0071477	cellular hypotonic salinity response
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140199

View Gene Order

ENSBTAG00000016236

Not yet available

Pathways

NETPATH

REACTOME

REACT_247550

SLC-mediated transmembrane transport pathway

REACT_251788

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_247880

Cation-coupled Chloride cotransporters pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19315

Cation-coupled Chloride cotransporters pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q924N4

TrEMBL

A2AGJ9 Q3UVD1 Q3V0N8

UniProt Splice Variant

Entrez Gene

107723

UniGene

Mm.398856 Mm.46449 Mm.485239

RefSeq

NM_133648 NM_133649 XM_006498545 XM_006498546

OMIM

CCDS

CCDS16551 CCDS16552

HPRD

IMGT

MGI ID

MGI:2135960

MGI Symbol

Slc12a6

EMBL

AF211854 AF211855 AK133006 AK137387 AL683897 AL713853 CH466519

GenPept

AAK81895 AAK81896 BAE21466 BAE23339 CAM17489 EDL27838

RNA Seq Atlas

107723