InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufv2

Summary

InnateDB Gene

IDBG-195310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufv2

Gene Name

NADH dehydrogenase (ubiquinone) flavoprotein 2

Synonyms

2900010C23Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024099

Encoded Proteins

IDBP-195312

NADH dehydrogenase (ubiquinone) flavoprotein 2

IDBP-541455

NADH dehydrogenase (ubiquinone) flavoprotein 2

IDBP-714831

IDBP-537400

NADH dehydrogenase (ubiquinone) flavoprotein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The bovine ortholog of this protein has been characterized and is reported to contain an iron-sulfur cluster, which may be involved in electron transfer. In humans mutations in this gene are implicated in Parkinson\'s disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:66078795-66101559

Strand

Reverse strand

Band

E1.1

Transcripts

ENSMUST00000024909	ENSMUSP00000024909
ENSMUST00000143987	ENSMUSP00000121557
ENSMUST00000138847	ENSMUSP00000137940
ENSMUST00000147484	ENSMUSP00000115317

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0007399	nervous system development
GO:0048738	cardiac muscle tissue development
GO:0055114	oxidation-reduction process