Version 5.4
Mus musculus Gene: Arrb2
Summary
InnateDB Gene IDBG-194248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arrb2
Gene Name arrestin, beta 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000060216
Encoded Proteins
IDBP-194250
arrestin, beta 2
IDBP-194252
arrestin, beta 2
IDBP-194254
arrestin, beta 2
IDBP-194256
arrestin, beta 2
IDBP-264255
arrestin, beta 2
IDBP-717831
IDBP-718691
IDBP-622970
arrestin, beta 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19783052
[Homo sapiens] ARRB2 acts to limit JNK/ERK activation and survival in macrophages and is required for basal and TLR-inducible complement C1q expression.
PMID 20497256
[Homo sapiens] ARRB2 regulates TLR4-mediated apoptotic signalling through GSK3B where ARRB2 represents an inhibitory effect on the TLR4-mediated apoptotic cascade, through controlling the homeostasis of activation and inactivation of GSK3B.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141480:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70432635-70440828
Strand Forward strand
Band B3
Transcripts
ENSMUST00000079056 ENSMUSP00000078065
ENSMUST00000102564 ENSMUSP00000099624
ENSMUST00000102563 ENSMUSP00000099623
ENSMUST00000084954 ENSMUSP00000082018
ENSMUST00000108568 ENSMUSP00000104208
ENSMUST00000124112
ENSMUST00000124943 ENSMUSP00000136978
ENSMUST00000150076 ENSMUSP00000136601
ENSMUST00000128748 ENSMUSP00000134349
ENSMUST00000138006
ENSMUST00000125441
ENSMUST00000143232
ENSMUST00000144454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 292 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0031691 alpha-1A adrenergic receptor binding
GO:0031692 alpha-1B adrenergic receptor binding
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031748 D1 dopamine receptor binding
GO:0031762 follicle-stimulating hormone receptor binding
GO:0031826 type 2A serotonin receptor binding
GO:0032403 protein complex binding
GO:0032947 protein complex scaffold
GO:0043422 protein kinase B binding
GO:0051019 mitogen-activated protein kinase binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G-protein coupled receptor internalization
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0006309 apoptotic DNA fragmentation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0015031 protein transport
GO:0016567 protein ubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031623 receptor internalization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034260 negative regulation of GTPase activity
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0042699 follicle-stimulating hormone signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051897 positive regulation of protein kinase B signaling
GO:0051928 positive regulation of calcium ion transport
GO:0060326 cell chemotaxis
GO:0060765 regulation of androgen receptor signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0014069 postsynaptic density
GO:0016323 basolateral plasma membrane
GO:0030139 endocytic vesicle
GO:0031410 cytoplasmic vesicle
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141480
View Gene Order
ENSBTAG00000035587
Not yet available
Pathways
NETPATH
REACTOME
REACT_222404
WNT5A-dependent internalization of FZD4 pathway
REACT_189085
Disease pathway
REACT_224553
Hemostasis pathway
REACT_214014
Signaling by Wnt pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_214043
PCP/CE pathway pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_220322
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
KEGG
mmu04740
Olfactory transduction pathway
mmu04010
MAPK signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu04144
Endocytosis pathway
mmu04744
Phototransduction pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_10
Hedgehog pathway
NetPath_25
FSH pathway
REACTOME
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_172581
PCP/CE pathway pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04740
Olfactory transduction pathway
hsa04010
MAPK signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa04744
Phototransduction pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
nfkappabatypicalpathway
Atypical NF-kappaB pathway
txa2pathway
Thromboxane A2 receptor signaling
cxcr4_pathway
CXCR4-mediated signaling events
alk1pathway
ALK1 signaling events
tgfbrpathway
TGF-beta receptor signaling
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.488859
RefSeq NM_001271358 NM_001271359 NM_001271360 NM_145429
OMIM
CCDS CCDS24946 CCDS70226
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca