InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ntf3

Summary

InnateDB Gene

IDBG-190188.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ntf3

Gene Name

neurotrophin 3

Synonyms

AI316846; AI835689; Nt3; Ntf-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000049107

Encoded Proteins

IDBP-190190

neurotrophin 3

IDBP-256423

neurotrophin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185652:
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:126101413-126166744

Strand

Reverse strand

Band

Transcripts

ENSMUST00000050484	ENSMUSP00000052302
ENSMUST00000112244	ENSMUSP00000107863

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005166	neurotrophin p75 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0002092	positive regulation of receptor internalization
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007274	neuromuscular synaptic transmission
GO:0007399	nervous system development
GO:0007403	glial cell fate determination
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007422	peripheral nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0021675	nerve development
GO:0030335	positive regulation of cell migration
GO:0032148	activation of protein kinase B activity
GO:0032856	activation of Ras GTPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042490	mechanoreceptor differentiation
GO:0042552	myelination
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045687	positive regulation of glial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048484	enteric nervous system development
GO:0048666	neuron development
GO:0048699	generation of neurons
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050804	regulation of synaptic transmission
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051145	smooth muscle cell differentiation
GO:2000251	positive regulation of actin cytoskeleton reorganization