Version 5.4
Mus musculus Gene: Ing4
Summary
InnateDB Gene IDBG-188872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ing4
Gene Name inhibitor of growth family, member 4
Synonyms D6Wsu147e; D6Xrf92; p29ING4
Species Mus musculus
Ensembl Gene ENSMUSG00000030330
Encoded Proteins
IDBP-188874
inhibitor of growth family, member 4
IDBP-256067
inhibitor of growth family, member 4
IDBP-538081
inhibitor of growth family, member 4
IDBP-534110
inhibitor of growth family, member 4
IDBP-541661
inhibitor of growth family, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20534538
Ing4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response in mice by facilitating NF-kappaB activation of IkappaB promoters; thereby suppressing nuclear Rela (p65) levels and the activation of select NF-kappaB target cytokines.
InnateDB Annotation from Orthologs
Summary
PMID 20534538
[Homo sapiens] ING4 is a member of the inhibitor of growth (ING) family of chromatin-modifying proteins that functions to negatively regulate the cytokine-mediated inflammatory response. In mice, it facilitates NF-kappaB activation of IkappaB promoters, thereby suppressing nuclear RelA (p65) levels and the activation of select NF-kappaB target cytokines.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111653:
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:125039760-125051499
Strand Forward strand
Band F2
Transcripts
ENSMUST00000032480 ENSMUSP00000032480
ENSMUST00000112417 ENSMUSP00000108036
ENSMUST00000140131 ENSMUSP00000121519
ENSMUST00000128277
ENSMUST00000140883 ENSMUSP00000118561
ENSMUST00000152574
ENSMUST00000151125 ENSMUSP00000119709
ENSMUST00000156091
ENSMUST00000133695
ENSMUST00000146229
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0006260 DNA replication
GO:0006473 protein acetylation
GO:0006915 apoptotic process
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043966 histone H3 acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045926 negative regulation of growth
Cellular Component
GO:0000123 histone acetyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111653
View Gene Order
ENSBTAG00000017064
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.262547 Mm.399689
RefSeq NM_133345
OMIM
CCDS CCDS39632
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca