Version 5.4
Mus musculus Gene: Ppp3cc
Summary
InnateDB Gene IDBG-178202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp3cc
Gene Name protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms Calnc
Species Mus musculus
Ensembl Gene ENSMUSG00000022092
Encoded Proteins
IDBP-178204
protein phosphatase 3, catalytic subunit, gamma isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120910:
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70217898-70289449
Strand Reverse strand
Band D2
Transcripts
ENSMUST00000078434 ENSMUSP00000077532
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005516 calmodulin binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120910
View Gene Order
ENSBTAG00000020133
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_254215
Signaling by GPCR pathway
REACT_203795
DARPP-32 events pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
mmu04360
Axon guidance pathway
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu05010
Alzheimer's disease pathway
mmu04660
T cell receptor signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu04210
Apoptosis pathway
mmu04662
B cell receptor signaling pathway pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04114
Oocyte meiosis pathway
mmu04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_14797
Signaling by GPCR pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04370
VEGF signaling pathway pathway
hsa04310
Wnt signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04720
Long-term potentiation pathway
hsa05010
Alzheimer's disease pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04114
Oocyte meiosis pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt P48455
TrEMBL Q3V074 Q80XK0
UniProt Splice Variant
Entrez Gene 19057
UniGene
RefSeq NM_008915
OMIM
CCDS CCDS36968
HPRD
IMGT
MGI ID MGI:107162
MGI Symbol Ppp3cc
EMBL AK133393 BC046617 BC141079 CH466535 M81475
GenPept AAA39968 AAH46617 AAI41080 BAE21630 EDL35913 EDL35914
RNA Seq Atlas 19057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca