InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fancd2

Summary

InnateDB Gene

IDBG-177677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fancd2

Gene Name

Fanconi anemia, complementation group D2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034023

Encoded Proteins

IDBP-177679

Fanconi anemia, complementation group D2

IDBP-177681

Fanconi anemia, complementation group D2

IDBP-537133

Fanconi anemia, complementation group D2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144554:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:113531682-113597017

Strand

Forward strand

Band

Transcripts

ENSMUST00000036340	ENSMUSP00000045667
ENSMUST00000101051	ENSMUSP00000098612
ENSMUST00000143535
ENSMUST00000142453
ENSMUST00000123738	ENSMUSP00000122091
ENSMUST00000129462
ENSMUST00000124262

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0070182	DNA polymerase binding

Biological Process

GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007129	synapsis
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0010332	response to gamma radiation