InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ifnar2

Summary

InnateDB Gene

IDBG-175856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifnar2

Gene Name

interferon (alpha and beta) receptor 2

Synonyms

AI747302; Ifnar-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022971

Encoded Proteins

IDBP-175858

interferon (alpha and beta) receptor 2

IDBP-175860

interferon (alpha and beta) receptor 2

IDBP-400874

interferon (alpha and beta) receptor 2

IDBP-707065

IDBP-707319

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12220192

[Homo sapiens] The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. Binding of interferon (IFN)-alpha to IFNAR2;IL10RB results in STAT2 binding and the initiation of the IFN signaling cascade.

PMID 20483775

[Homo sapiens] Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159110:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:91372783-91405589

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000023693	ENSMUSP00000023693
ENSMUST00000089042	ENSMUSP00000086443
ENSMUST00000117836	ENSMUSP00000113358
ENSMUST00000134491	ENSMUSP00000134796
ENSMUST00000139503	ENSMUSP00000135322

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004905	type I interferon receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019962	type I interferon binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0035455	response to interferon-alpha
GO:0060337	type I interferon signaling pathway