Version 5.4
Mus musculus Gene: Rad18
Summary
InnateDB Gene IDBG-175180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rad18
Gene Name RAD18 homolog (S. cerevisiae)
Synonyms 2810024C04Rik; Rad18sc
Species Mus musculus
Ensembl Gene ENSMUSG00000030254
Encoded Proteins
IDBP-175182
RAD18 homolog (S. cerevisiae)
IDBP-175184
RAD18 homolog (S. cerevisiae)
IDBP-254420
RAD18 homolog (S. cerevisiae)
IDBP-254422
RAD18 homolog (S. cerevisiae)
IDBP-538214
RAD18 homolog (S. cerevisiae)
IDBP-789692
RAD18 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070950:
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:112619850-112696686
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000077088 ENSMUSP00000076341
ENSMUST00000068487 ENSMUSP00000070619
ENSMUST00000113182 ENSMUSP00000108807
ENSMUST00000113180 ENSMUSP00000108805
ENSMUST00000142079 ENSMUSP00000117582
ENSMUST00000132590
ENSMUST00000156063 ENSMUSP00000138558
ENSMUST00000135092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000403 Y-form DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031593 polyubiquitin binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0009411 response to UV
GO:0016567 protein ubiquitination
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000785 chromatin
GO:0001741 XY body
GO:0005634 nucleus
GO:0005657 replication fork
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070950
View Gene Order
ENSBTAG00000012142
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.103812 Mm.421960
RefSeq NM_001167730 NM_021385
OMIM
CCDS CCDS39589 CCDS51870
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca