Version 5.4
Mus musculus Gene: Ephx2
Summary
InnateDB Gene IDBG-174962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ephx2
Gene Name epoxide hydrolase 2, cytoplasmic
Synonyms CEH; Eph2; SEH; sEP
Species Mus musculus
Ensembl Gene ENSMUSG00000022040
Encoded Proteins
IDBP-174964
epoxide hydrolase 2, cytoplasmic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120915:
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:66084377-66124500
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000070515 ENSMUSP00000069209
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004301 epoxide hydrolase activity
GO:0005102 receptor binding
GO:0015643 toxic substance binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity
GO:0042577 lipid phosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0016311 dephosphorylation
GO:0042632 cholesterol homeostasis
GO:0046272 stilbene catabolic process
GO:0046839 phospholipid dephosphorylation
GO:0090181 regulation of cholesterol metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005925 focal adhesion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120915
View Gene Order
ENSBTAG00000015241
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_196570
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
mmu00590
Arachidonic acid metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150417
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
hsa04146
Peroxisome pathway
INOH
PID NCI
Cross-References
SwissProt P34914
TrEMBL A8JYK8
UniProt Splice Variant
Entrez Gene 13850
UniGene Mm.15295
RefSeq NM_001271402 NM_001271403 NM_007940
OMIM
CCDS CCDS27218
HPRD
IMGT
MGI ID MGI:99500
MGI Symbol Ephx2
EMBL AY098585 BC015087 EF597241 L05781 Z37107
GenPept AAA37555 AAH15087 AAM28238 ABU95055 CAA85471
RNA Seq Atlas 13850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca