Mus musculus Gene: Siva1 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-174589.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Siva1 | ||||||||||
Gene Name | SIVA1, apoptosis-inducing factor | ||||||||||
Synonyms | CD27bp; Siva | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000064326 | ||||||||||
Encoded Proteins |
SIVA1, apoptosis-inducing factor
SIVA1, apoptosis-inducing factor
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
InnateDB Annotation from Orthologs | |||||||||||
Summary |
[Homo sapiens] SIVA1 diminishes NFkappaB and enhances JNK activity to favour apoptosis by physically interacting with MAP3K7 (TAK1) and XIAP.
[Homo sapiens] SIVA1 promotes K-48 polyubiquitination of TRAF2 and inhibits TCR-mediated activation of NF-kappaB.
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Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184990:
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 12:112644828-112649152 | ||||||||||
Strand | Forward strand | ||||||||||
Band | F1 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Cross-References | |||||||||||
SwissProt | O54926 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 30954 | ||||||||||
UniGene | Mm.407012 | ||||||||||
RefSeq | NM_001161737 NM_013929 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS49189 CCDS26193 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | MGI:1353606 | ||||||||||
MGI Symbol | Siva1 | ||||||||||
EMBL | AF033112 AF033113 AF033114 AF033115 AK010562 AK017570 AK153115 BC012279 | ||||||||||
GenPept | AAC04706 AAD50058 AAD50059 AAD50060 AAH12279 BAB27029 BAB30811 BAE31732 | ||||||||||
RNA Seq Atlas | 30954 | ||||||||||