InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tcf3

Summary

InnateDB Gene

IDBG-174161.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tcf3

Gene Name

transcription factor 3

Synonyms

A1; AA408400; ALF2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020167

Encoded Proteins

IDBP-174163

transcription factor 3

IDBP-174165

transcription factor 3

IDBP-271071

transcription factor 3

IDBP-271073

transcription factor 3

IDBP-271075

transcription factor 3

IDBP-271077

transcription factor 3

IDBP-271079

transcription factor 3

IDBP-271081

transcription factor 3

IDBP-271083

transcription factor 3

IDBP-271085

transcription factor 3

IDBP-533543

transcription factor 3

IDBP-539556

transcription factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071564:
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80409514-80433647

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020377	ENSMUSP00000020377
ENSMUST00000020379	ENSMUSP00000020379
ENSMUST00000105346	ENSMUSP00000100983
ENSMUST00000105345	ENSMUSP00000100982
ENSMUST00000105344	ENSMUSP00000100981
ENSMUST00000105343	ENSMUSP00000100980
ENSMUST00000105342	ENSMUSP00000100979
ENSMUST00000105341	ENSMUSP00000100978
ENSMUST00000105340	ENSMUSP00000100977
ENSMUST00000105339	ENSMUSP00000100976
ENSMUST00000156990	ENSMUSP00000121172
ENSMUST00000129027
ENSMUST00000127931
ENSMUST00000156244	ENSMUSP00000120303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
They are also associated with 129 interaction(s) predicted by orthology.

Experimentally validated
Total	128 [view]
Protein-Protein	119 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	129 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0042803	protein homodimerization activity
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070491	repressing transcription factor binding
GO:0070644	vitamin D response element binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001779	natural killer cell differentiation
GO:0002326	B cell lineage commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007369	gastrulation
GO:0010628	positive regulation of gene expression
GO:0030098	lymphocyte differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0032496	response to lipopolysaccharide
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0042493	response to drug
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045666	positive regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048541	Peyer's patch development
GO:0050821	protein stabilization
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000788	nuclear nucleosome
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0043234	protein complex