Version 5.4
Mus musculus Gene: Grik1
Summary
InnateDB Gene IDBG-173771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grik1
Gene Name glutamate receptor, ionotropic, kainate 1
Synonyms A830007B11Rik; D16Ium24; D16Ium24e; GluK1; GluK5; Glur-5; Glur5; Glurbeta1
Species Mus musculus
Ensembl Gene ENSMUSG00000022935
Encoded Proteins
IDBP-173773
glutamate receptor, ionotropic, kainate 1
IDBP-173775
glutamate receptor, ionotropic, kainate 1
IDBP-252396
glutamate receptor, ionotropic, kainate 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:87896196-88056176
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000072256 ENSMUSP00000072107
ENSMUST00000023652 ENSMUSP00000023652
ENSMUST00000114137 ENSMUSP00000109773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0015277 kainate selective glutamate receptor activity
Biological Process
GO:0006810 transport
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0030534 adult behavior
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0048266 behavioral response to pain
GO:0051899 membrane depolarization
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060080 regulation of inhibitory postsynaptic membrane potential
Cellular Component
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0097481 neuronal postsynaptic density
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171189
View Gene Order
ENSBTAG00000034854
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_21343
Activation of Na-permeable Kainate Receptors pathway
REACT_13685
Neuronal System pathway
REACT_21322
Ionotropic activity of Kainate Receptors pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21346
Activation of Ca-permeable Kainate Receptor pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.403860 Mm.5134
RefSeq NM_010348 NM_146072 XM_006522917
OMIM
CCDS
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca