InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bach1

Summary

InnateDB Gene

IDBG-173699.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bach1

Gene Name

BTB and CNC homology 1

Synonyms

6230421P05Rik; AI323795

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025612

Encoded Proteins

IDBP-173701

BTB and CNC homology 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156273:
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:87698945-87733346

Strand

Forward strand

Band

C3.3

Transcripts

ENSMUST00000026703	ENSMUSP00000026703
ENSMUST00000151046
ENSMUST00000156958

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156273

View Gene Order

ENSBTAG00000004139

Not yet available

Cross-References

SwissProt

P97302

TrEMBL

Q3URL4

UniProt Splice Variant

Entrez Gene

12013

UniGene

Mm.26147 Mm.382122 Mm.394831

RefSeq

NM_007520 XM_006522879

OMIM

CCDS

CCDS28293

HPRD

IMGT

MGI ID

MGI:894680

MGI Symbol

Bach1

EMBL

AK141405 BC057894 CH466521 D86603

GenPept

AAH57894 BAA13137 BAE24674 EDK98341

RNA Seq Atlas

12013